Poe is Rottytops and Abner Cadaver's brother. While his siblings are mischievous and gruff with others, Poe is always incredibly polite. The worst thing you can say about him is that he's got a bizarre taste in coffee. He is responsible for the upkeep of Rotty's wagon during Shantae and the Pirate's Curse.
The brothers do not appear in the original game, but they are mentioned fearfully by other zombies at the Zombie Caravan. Shantae is told that she is fortunate that they are not around because they are a lot of trouble.
In Risky's Revenge, Abner Cadaver and Poe appear together three times. First, they are waiting for Shantae at the exit of a Tangled Forest Cave where the Elephant Magic Fountain is located. They strike a deal with her: providing her with a tool to get in Hypno Tower in exchange for coffee with a rotten egg (as they inform her that coffee is the only thing preventing zombies such as them to become mindless). Shantae meets them for the second time at the Boat House, where she exchanges coffee for what happens to be explosives to blow up the grid at the Tower's entrance. They appear one last time alongside Rottytops in Risky's Lair near the end of the game, having abducted Mimic in exchange for a lifetime supply of coffee (and in the case of Rotty, for Shantae's brains). However, Risky backs down from the deal, and the trio is last seen bitterly leaving the Lair, just as Shantae arrives.
On Spiderweb Island, Rottytops and Abner ask Shantae to look for Poe, who has gone missing. When Shantae finds him, he is trying to repair Rottytops' wagon so the siblings could get off the island and reunite with the Zombie Caravan. However, he needs Squid Oil in order for the axles of the wheels to run smoothly. Once Shantae hands over the Squid Oil received from the Squid Baron, Poe finishes repairing the wagon and offers the Shrunken Head, an item needed to enter Cackle Tower, as a reward. Afterward, Poe can take Shantae through the Ghost Forest and to the other side of the island when asked.
At the end, it is revealed that the zombies have moved back to the mainland. After leaving Rottytops in the care of Shantae at Shantae's Lighthouse, Poe and Abner Cadaver leave together in search of their former identity, and also of the Zombie Caravan, which they plan to re-join.
Poe appears in Hypno Baron's Castle. He gives his pet Zombie Hamster to Shantae as a component for the Dynamo, as he's worried about letting it run loose in the castle and wants to make sure it gets enough exercise without getting lost or hurt.
Abner later mentions that Poe goes to "nerd-cons" while giving Shantae one of Poe's posters for a quest.